Publications
2020
Natural infection with Giardia is associated with altered community structure of the human and canine gut microbiome
mSphere. Aug 05 2020. PDF | CodeActivation of p38α stress-activated protein kinase drives the formation of the pre-metastatic niche in the lungs
Nature Cancer. May 25 2020 PDF.Xenosiderophore utilization promotes Bacteroides thetaiotaomicron resilience during colitis
Cell Host Microbe. Feb 18 2020 PDF.The parasite kinase ROP16 is a key virulence factor that acts in cis and trans and mediates suppression of T cell responses
. Journal of Experimental Medicine. Jan 20 2020 PDF.2019
OHMI: The Ontology of Host-Microbiome Interactions
Journal of Biomedical Semantics. Dec 30 2019 PDF.Variable gene expression and parasite load predict treatment outcome in cutaneous leishmaniasis
Science Translational Medicine. Nov 20; 2019 PDF | CodeLifecycle progression and sexual development of the apicomplexan parasite Cryptosporidium parvum
Nature Microbiology. Sept 02; 2019. PDF | CodeDiet-induced remission in chronic enteropathy is associated with altered microbial community structure and synthesis of secondary bile acids
Microbiome. Aug 31; 2019. PDF | . CodeGut microbiota features associated with Clostridioides difficile colonization in puppies
PLOS One. Aug 30; 2019. PDF.Fibroblast activation protein restrains adipogenic differentiation and regulats matrix-mediated mTOR signaling
Matrix Biology. July 17; 2019. PDF.Infection-Induced Intestinal Dysbiosis Is Mediated by Macrophage Activation and Nitrate Production
MBio. May 28; 2019. PDF.IL-27 and TCR Stimulation Promote T Cell Expression of Multiple Inhibitory Receptors
ImmunoHorizons. Jan 01; 2019. PDF.2018
Alarmin S100A11 initiates a chemokine response to the human pathogen Toxoplasma gondii
Nature Immunology. Nov 19; 2018. PDF.Glycolysis is important for optimal asexual growth and formation of mature tissue cysts by Toxoplasma gondii
International journal for parasitology. Aug 31; 2018. PDF.Sex-specific gene expression differences are evident in human embryonic stem cells and during in vitro differentiation of human placental progenitor cells
Stem Cells and Development. July 11; 2018 PDF.The maternal vaginal microbiome partially mediates the effects of prenatal stress on offspring gut and hypothalamus.
Nature Neuroscience. July 9; 2018Culture-independent profiling of the stool microbiome to identify microbial species associated with a diarrheal outbreak in an immunocompromised mouse colony.
Comparative Medicine. June 13; 2018Commensal microbes induce serum IgA responses that protect against polymicrobial sepsis.
Cell Host Microbe. Feb 22; 2018CD8+ T cells lack local signals to produce IFN-γ in the skin during leishmania infection.
Journal of Immunology. Jan 24; 2018MicrobiomeDB: a systems biology platform for integrating, mining and analyzing microbiome experiments
Nucleic Acids Research. Jan 4; 20182017
Involvement of Innate Immune System in Late Stages of Inherited Photoreceptor Degeneration.
Scientific Reports. Dec 20; 2017Replication Defective Viral Genomes Exploit A Cellular Pro-Survival Mechanism To Establish Viral Persistence.
Nature Communications. Oct 6; 2017An oxidative central metabolism enables Salmonella to utilize microbiota-derived succinate.
Cell Host and Microbe. Sept 13; 2017Cutaneous leishmaniasis induces a transmissible dysbiotic skin microbiome that promotes increased skin inflammation.
Cell Host and Microbe. July 12; 2017Stress during pregnancy alters temporal and spatial dynamics of the maternal and offspring microbiome in a sex-specific manner
Scientific Reports. Mar 7; 2017T Regulatory Cells Support Plasma Cell Populations in the Bone Marrow.
Cell Reports. Feb 21; 2017CD8 T cell cytotoxicity mediates pathology in the skin by inflammasome activation and IL-1β production.
PLOS Pathogens. Feb 13; 2017Inactivation of interferon receptor promotes the establishment of immune privileged tumor microenvironment.
Cancer Cell. Feb 13; 20172016
STAT1 signaling in astrocytes is essential for control of Toxoplasma gondii in the central nervous system.
MBio. Nov 8; 2016Activity of uncleaved caspase-8 controls anti-bacterial immune defense and TLR-induced cytokine production independent of cell death.
PLOS Pathogens. Oct 13; 2016Divergent isoprenoid biosynthesis pathways in Staphylococcus species constitute a drug target for treating infections in companion animals.
mSphere. Sept 28; 2016Meta-transcriptome profiling of the human-Leishmania braziliensis cutaneous lesion.
PLOS Neglected Tropical Diseases. Sept 15; 2016Cutting Edge: IL-4, IL-21, and IFN-g Interact to Govern TBET and CD11c Expression in TLR-Activated B Cells.
Cutting Edge: Journal of Immunology. July 18; 2016Suppression of type I interferon signaling overcomes the oncogene-induced senescence and mediates melanoma development and progression.
Cell Reports. April 5; 2016T Cell Receptor-Induced NF-kB signaling and transcriptional activation are regulated by STIM1- and Orai1-mediated calcium entry.
J Biol Chem. Jan 29; 2016Type I Interferons Control Proliferation and Function of Intestinal Epithelium.
Mol Cell Biol. Jan 25; 20162015
IL-4 dependent, eosinophil-mediated support of nematode growth occurs in the context of an innate response to tissue injury.
PLOS Pathogens. Dec 31;11(12)image selected as PLOS Pathogens feature image for Jan 2016
Genome sequencing reveals clonal dynamics of methicillin-resistant Staphylococcus aureus in the same household in the context of clinical disease in a person and a dog
Veterinary Microbiology. Nov 18;180(3-4):304-7Complete genome sequence and methylome of Staphylococcus schleiferi, an important cause of skin and ear infections in veterinary medicine.
Genome Announcements. Sep 10;3(5)Skin Resident Memory CD4+ T Cells Enhance Protection Against leishmania major Infection.
Journal of Experimental Medicine. vol. 212 no. 9also see symposis titled Skin-resident T cells keep parasites on a leish
The Orphan Nuclear Receptor TLX is an Enhancer of STAT1-mediated Transcription and Immunity to Toxoplasma gondii.
PLOS Biology. Jul 21;13(7)also see symposis titled Tuning up STAT1
2014
Matrix metalloproteinase 9 production by monocytes is enhanced by TNF-α and participates in the pathology of human cutaneous leishmaniasis.
PLOS Neglected Tropical Diseases. Nov 13;8(11)Intermediate monocytes contribute to pathologic immune response during leishmania braziliensis infection.
Journal of Infectious Diseases. Jan 15;211(2):274-82Protozoan Parasites and Type I Interferon: A Cold Case Reopened.
Trends in Parasitology. Oct;30(10):491-8Genomic Profiling of human leishmania braziliensis lesions identifies transcriptional modules associated with cutaneous immunopathology.
Journal of Investigative Dermatology. Jan;135(1):94-101Bystander chronic infection negatively impacts development of CD8+ T cell memory.
Immunity. May 15;40(5):801-13Differential Induction of TLR3-dependent Innate Immune Signaling by Closely Related Parasite Species.
PLOS One. Feb 5;9(2)Human Classical Monocytes Control the Intracellular Stage of leishmania braziliensis by Reactive Oxygen Species.
Journal of Infectious Diseases. Apr 15;209(8):1288-962013
Cytotoxic T cells Mediate Pathology and Metastasis in Cutaneous leishmaniasis.
PLOS Pathogens. July;9(7)2012 and earlier
The cytokines interleukin 27 and interferon-γ promote distinct Treg cell populations required to limit infection-induced pathology.
Immunity. Sep 21;37(3):511-23Natural resistance-associated macrophage protein is a cellular receptor for sindbis virus in both insect and mammalian hosts.
Cell Host and Microbe. Aug 18;10(2):97-104A systems biological view of intracellular pathogens.
Immunological Reviews. Mar;240(1):117-28Integrative genomic approaches highlight a family of parasite-specific kinases that regulate host responses.
Cell Host and Microbe. Aug 19;8(2):208-18Combinatorial effects of interleukin 10 and interleukin 4 determine the progression of hepatic inflammation following murine enteric parasitic infection.
Hepatology. Jun;51(6):2162-71Apicomplexan parasites co-opt host calpains to facilitate their escape from infected cells.
Science. May 8;324(5928):794-7Eosinophil deficiency compromises parasite survival in chronic nematode infection.
The Journal of Immunology. Feb 1;182(3):1577-83Immunity to Trichinella spiralis muscle infection.
Veterinary Parasitology. Feb 23;159(3-4):245-8*Co-first authors
