Natural infection with Giardia is associated with altered community structure of the human and canine gut microbiomemSphere. Aug 05 2020. PDF | Code
Activation of p38α stress-activated protein kinase drives the formation of the pre-metastatic niche in the lungsNature Cancer. May 25 2020 PDF.
The parasite kinase ROP16 is a key virulence factor that acts in cis and trans and mediates suppression of T cell responses. Journal of Experimental Medicine. Jan 20 2020 PDF.
Diet-induced remission in chronic enteropathy is associated with altered microbial community structure and synthesis of secondary bile acidsMicrobiome. Aug 31; 2019. PDF | . Code
Fibroblast activation protein restrains adipogenic differentiation and regulats matrix-mediated mTOR signalingMatrix Biology. July 17; 2019. PDF.
Glycolysis is important for optimal asexual growth and formation of mature tissue cysts by Toxoplasma gondiiInternational journal for parasitology. Aug 31; 2018. PDF.
Sex-specific gene expression differences are evident in human embryonic stem cells and during in vitro differentiation of human placental progenitor cellsStem Cells and Development. July 11; 2018 PDF.
The maternal vaginal microbiome partially mediates the effects of prenatal stress on offspring gut and hypothalamus.Nature Neuroscience. July 9; 2018
Culture-independent profiling of the stool microbiome to identify microbial species associated with a diarrheal outbreak in an immunocompromised mouse colony.Comparative Medicine. June 13; 2018
MicrobiomeDB: a systems biology platform for integrating, mining and analyzing microbiome experimentsNucleic Acids Research. Jan 4; 2018
Replication Defective Viral Genomes Exploit A Cellular Pro-Survival Mechanism To Establish Viral Persistence.Nature Communications. Oct 6; 2017
Cutaneous leishmaniasis induces a transmissible dysbiotic skin microbiome that promotes increased skin inflammation.Cell Host and Microbe. July 12; 2017
Stress during pregnancy alters temporal and spatial dynamics of the maternal and offspring microbiome in a sex-specific mannerScientific Reports. Mar 7; 2017
CD8 T cell cytotoxicity mediates pathology in the skin by inflammasome activation and IL-1β production.PLOS Pathogens. Feb 13; 2017
Inactivation of interferon receptor promotes the establishment of immune privileged tumor microenvironment.Cancer Cell. Feb 13; 2017
STAT1 signaling in astrocytes is essential for control of Toxoplasma gondii in the central nervous system.MBio. Nov 8; 2016
Activity of uncleaved caspase-8 controls anti-bacterial immune defense and TLR-induced cytokine production independent of cell death.PLOS Pathogens. Oct 13; 2016
Divergent isoprenoid biosynthesis pathways in Staphylococcus species constitute a drug target for treating infections in companion animals.mSphere. Sept 28; 2016
Cutting Edge: IL-4, IL-21, and IFN-g Interact to Govern TBET and CD11c Expression in TLR-Activated B Cells.Cutting Edge: Journal of Immunology. July 18; 2016
Suppression of type I interferon signaling overcomes the oncogene-induced senescence and mediates melanoma development and progression.Cell Reports. April 5; 2016
T Cell Receptor-Induced NF-kB signaling and transcriptional activation are regulated by STIM1- and Orai1-mediated calcium entry.J Biol Chem. Jan 29; 2016
IL-4 dependent, eosinophil-mediated support of nematode growth occurs in the context of an innate response to tissue injury.PLOS Pathogens. Dec 31;11(12)
image selected as PLOS Pathogens feature image for Jan 2016
Genome sequencing reveals clonal dynamics of methicillin-resistant Staphylococcus aureus in the same household in the context of clinical disease in a person and a dogVeterinary Microbiology. Nov 18;180(3-4):304-7
Complete genome sequence and methylome of Staphylococcus schleiferi, an important cause of skin and ear infections in veterinary medicine.Genome Announcements. Sep 10;3(5)
also see symposis titled Skin-resident T cells keep parasites on a leish
The Orphan Nuclear Receptor TLX is an Enhancer of STAT1-mediated Transcription and Immunity to Toxoplasma gondii.PLOS Biology. Jul 21;13(7)
also see symposis titled Tuning up STAT1
Matrix metalloproteinase 9 production by monocytes is enhanced by TNF-α and participates in the pathology of human cutaneous leishmaniasis.PLOS Neglected Tropical Diseases. Nov 13;8(11)
Intermediate monocytes contribute to pathologic immune response during leishmania braziliensis infection.Journal of Infectious Diseases. Jan 15;211(2):274-82
Genomic Profiling of human leishmania braziliensis lesions identifies transcriptional modules associated with cutaneous immunopathology.Journal of Investigative Dermatology. Jan;135(1):94-101
Differential Induction of TLR3-dependent Innate Immune Signaling by Closely Related Parasite Species.PLOS One. Feb 5;9(2)
Human Classical Monocytes Control the Intracellular Stage of leishmania braziliensis by Reactive Oxygen Species.Journal of Infectious Diseases. Apr 15;209(8):1288-96
2012 and earlier
The cytokines interleukin 27 and interferon-γ promote distinct Treg cell populations required to limit infection-induced pathology.Immunity. Sep 21;37(3):511-23
Natural resistance-associated macrophage protein is a cellular receptor for sindbis virus in both insect and mammalian hosts.Cell Host and Microbe. Aug 18;10(2):97-104
Integrative genomic approaches highlight a family of parasite-specific kinases that regulate host responses.Cell Host and Microbe. Aug 19;8(2):208-18
Combinatorial effects of interleukin 10 and interleukin 4 determine the progression of hepatic inflammation following murine enteric parasitic infection.Hepatology. Jun;51(6):2162-71