Impact of secondary TCR engagement on the heterogeneity of pathogen-specific CD8+ T cell response during acute and chronic toxoplasmosisPLOS Pathogens . In Press. PDF |
Chronic Hypoxemia Induces Mitochondrial Respiratory Complex Gene Expression in the Fetal Sheep BrainThe Journal of Thoracic and Cardiovascular Surgery (JCTVS) Open . In Press. PDF |
Nature Cancer. In Press. PDF |
BioRxiv. Preprint. PDF |
A genetic screen identifies a protective type III interferon response to Cryptosporidium that requires TLR3 dependent recognitionPLOS Pathogens. In Press. PDF |
Book Chapter: Yamada's Textbook of Gastroenterology, 3 Volume Set, 7th Edition. April 2022 Publisher's website |
Re-establishment of spermatogenesis after more than 20 years of cryopreservation of rat spermatogonial stem cells reveals an important impact in differentiation capacityPLOS Biology. May 10 2022. PDF |
Crosstalk between enterocytes and innate lymphoid cells drives early IFN-γ-mediated control of CryptosporidiumMucosal Immunology. Nov 8 2021. PDF |
The Card19 locus of murine chromosome 13 regulates terminal cell lysis downstream of caspase activation and Gasdermin-D cleavagePLOS Pathogens. October 14 2021. PDF |
mBio. July 6 2021. PDF
Microbiome. June 27 2021. PDF | Code | Video abstract
Regulation of the intercellular biomolecule transfer-driven tumor angiogenesis, growth, and responses to anti-cancer therapiesJournal of Clinical Investigation. May 17 2021. PDF
Localized skin inflammation during cutaneous leishmaniasis drives a chronic, systemic IFN-γ signaturePLOS Neglected Tropical Diseases. April 1 2021. PDF
Mutations Affecting HVO_1357 or HVO_2248 Cause Hypermotility in Haloferax volcanii, Suggesting Roles in Motility RegulationGenes. Dec 31 2020. PDF
Natural infection with Giardia is associated with altered community structure of the human and canine gut microbiomemSphere. Aug 05 2020. PDF | Code
Activation of p38α stress-activated protein kinase drives the formation of the pre-metastatic niche in the lungsNature Cancer. May 25 2020. PDF.
Cell Host Microbe. Feb 18 2020. PDF.
Journal of Experimental Medicine. Jan 20 2020. PDF.
Journal of Biomedical Semantics. Dec 30 2019. PDF.
Science Translational Medicine. Nov 20; 2019. PDF | Code | Cover
Nature Microbiology. Sept 02; 2019. PDF | Code
Diet-induced remission in chronic enteropathy is associated with altered microbial community structure and synthesis of secondary bile acidsMicrobiome. Aug 31; 2019. PDF | Code
PLOS One. Aug 30; 2019. PDF.
Fibroblast activation protein restrains adipogenic differentiation and regulats matrix-mediated mTOR signalingMatrix Biology. July 17; 2019. PDF.
MBio. May 28; 2019. PDF.
ImmunoHorizons. Jan 01; 2019. PDF.
Nature Immunology. Nov 19; 2018. PDF.
Glycolysis is important for optimal asexual growth and formation of mature tissue cysts by Toxoplasma gondiiInternational journal for parasitology. Aug 31; 2018. PDF.
Sex-specific gene expression differences are evident in human embryonic stem cells and during in vitro differentiation of human placental progenitor cellsStem Cells and Development. July 11; 2018. PDF.
The maternal vaginal microbiome partially mediates the effects of prenatal stress on offspring gut and hypothalamus.Nature Neuroscience. July 9; 2018. PDF.
Culture-independent profiling of the stool microbiome to identify microbial species associated with a diarrheal outbreak in an immunocompromised mouse colony.Comparative Medicine. June 13; 2018. PDF.
Cell Host Microbe. Feb 22; 2018. PDF.
Journal of Immunology. Jan 24; 2018. PDF.
MicrobiomeDB: a systems biology platform for integrating, mining and analyzing microbiome experimentsNucleic Acids Research. Jan 4; 2018. PDF.
Scientific Reports. Dec 20; 2017. PDF.
Replication Defective Viral Genomes Exploit A Cellular Pro-Survival Mechanism To Establish Viral Persistence.Nature Communications. Oct 6; 2017. PDF.
Cell Host and Microbe. Sept 13; 2017. PDF.
Cutaneous leishmaniasis induces a transmissible dysbiotic skin microbiome that promotes increased skin inflammation.Cell Host and Microbe. July 12; 2017. PDF.
Stress during pregnancy alters temporal and spatial dynamics of the maternal and offspring microbiome in a sex-specific mannerScientific Reports. Mar 7; 2017. PDF.
Cell Reports. Feb 21; 2017. PDF.
CD8 T cell cytotoxicity mediates pathology in the skin by inflammasome activation and IL-1β production.PLOS Pathogens. Feb 13; 2017. PDF.
Inactivation of interferon receptor promotes the establishment of immune privileged tumor microenvironment.Cancer Cell. Feb 13; 2017. PDF.
STAT1 signaling in astrocytes is essential for control of Toxoplasma gondii in the central nervous system.MBio. Nov 8; 2016. PDF.
Activity of uncleaved caspase-8 controls anti-bacterial immune defense and TLR-induced cytokine production independent of cell death.PLOS Pathogens. Oct 13; 2016. PDF.
Divergent isoprenoid biosynthesis pathways in Staphylococcus species constitute a drug target for treating infections in companion animals.mSphere. Sept 28; 2016. PDF | Cover
PLOS Neglected Tropical Diseases. Sept 15; 2016. PDF.
Cutting Edge: IL-4, IL-21, and IFN-g Interact to Govern TBET and CD11c Expression in TLR-Activated B Cells.Cutting Edge: Journal of Immunology. July 18; 2016. PDF.
Suppression of type I interferon signaling overcomes the oncogene-induced senescence and mediates melanoma development and progression.Cell Reports. April 5; 2016. PDF.
T Cell Receptor-Induced NF-kB signaling and transcriptional activation are regulated by STIM1- and Orai1-mediated calcium entry.J Biol Chem. Jan 29; 2016. <a href="http://hostmicrobe.github.io/pubs/Freedman_JBC_2016.pdf target="_blank">PDF</a>.
Mol Cell Biol. Jan 25; 2016. PDF.
IL-4 dependent, eosinophil-mediated support of nematode growth occurs in the context of an innate response to tissue injury.PLOS Pathogens. Dec 31; 2015. PDF | Cover
Genome sequencing reveals clonal dynamics of methicillin-resistant Staphylococcus aureus in the same household in the context of clinical disease in a person and a dogVeterinary Microbiology. Nov 18; 2015. PDF.
Complete genome sequence and methylome of Staphylococcus schleiferi, an important cause of skin and ear infections in veterinary medicine.Genome Announcements. Sept 10; 2015. PDF.
Journal of Experimental Medicine. July 27; 2015. PDF | Synopsis
The Orphan Nuclear Receptor TLX is an Enhancer of STAT1-mediated Transcription and Immunity to Toxoplasma gondii.PLOS Biology. Jul 21; 2015. PDF | Synopsis
Matrix metalloproteinase 9 production by monocytes is enhanced by TNF-α and participates in the pathology of human cutaneous leishmaniasis.PLOS Neglected Tropical Diseases. Nov 13; 2014. PDF.
Intermediate monocytes contribute to pathologic immune response during leishmania braziliensis infection.Journal of Infectious Diseases. Jan 15; 2014. PDF.
Trends in Parasitology. Oct 30; 2014. PDF.
Genomic Profiling of human leishmania braziliensis lesions identifies transcriptional modules associated with cutaneous immunopathology.Journal of Investigative Dermatology. May 6; 2014. PDF.
Immunity. May 15; 2014. PDF.
Differential Induction of TLR3-dependent Innate Immune Signaling by Closely Related Parasite Species.PLOS One. Feb 5; 2014. PDF.
Human Classical Monocytes Control the Intracellular Stage of leishmania braziliensis by Reactive Oxygen Species.Journal of Infectious Diseases. Apr 15; 2014. PDF.
PLOS Pathogens. July 9; 2013. PDF.
2012 and earlier
The cytokines interleukin 27 and interferon-γ promote distinct Treg cell populations required to limit infection-induced pathology.Immunity. Sep 13; 2012. PDF.
Natural resistance-associated macrophage protein is a cellular receptor for sindbis virus in both insect and mammalian hosts.Cell Host and Microbe. Aug 18; 2011. PDF.
Immunological Reviews. Feb 23; 2011. PDF.
Integrative genomic approaches highlight a family of parasite-specific kinases that regulate host responses.Cell Host and Microbe. Aug 19; 2010. PDF.
Combinatorial effects of interleukin 10 and interleukin 4 determine the progression of hepatic inflammation following murine enteric parasitic infection.Hepatology. May 23; 2010. PDF.
Science. May 8; 2009. PDF.
The Journal of Immunology. Feb 1; 2009. PDF.
Veterinary Parasitology. Feb 23; 2009. PDF.
The Journal of Immunology. Jun 15; 2007. PDF.
Coordinated control of immunity to muscle stage Trichinella spiralis by IL-10, regulatory T cells, and TGF-beta.The Journal of Immunology. Jan 15; 2007. PDF.
Synthesis of syndecan-1 by skeletal muscle cells is an early response to infection with Trichinella spiralis but is not essential for nurse cell development.Infection and Immunity. Feb 22; 2006. PDF.
Interleukin-10 limits local and body cavity inflammation during infection with muscle-stage Trichinella spiralis.Infection and Immunity. May 20; 2004. PDF.
Mol Biochem Parasitol. April 25; 2002. PDF.