Publications
Preprints
Natural infection with Giardia is associated with altered community structure of the human and canine gut microbiome
BioRxiv. Jan 14 20202020
Xenosiderophore utilization promotes Bacteroides thetaiotaomicron resilience during colitis
Cell Host Microbe. Feb 18 2020The parasite kinase ROP16 is a key virulence factor that acts in cis and trans and mediates suppression of T cell responses
. Journal of Experimental Medicine. Jan 20 20202019
OHMI: The Ontology of Host-Microbiome Interactions
Journal of Biomedical Semantics. Dec 30; 2019Variable gene expression and parasite load predict treatment outcome in cutaneous leishmaniasis
Science Translational Medicine. Nov 20; 2019Lifecycle progression and sexual development of the apicomplexan parasite Cryptosporidium parvum
Nature Microbiology. Sept 02; 2019Diet-induced remission in chronic enteropathy is associated with altered microbial community structure and synthesis of secondary bile acids
Microbiome. Aug 31; 2019Gut microbiota features associated with Clostridioides difficile colonization in puppies
PLOS One. Aug 30; 2019Fibroblast activation protein restrains adipogenic differentiation and regulats matrix-mediated mTOR signaling
Matrix Biology. July 17; 2019Infection-Induced Intestinal Dysbiosis Is Mediated by Macrophage Activation and Nitrate Production
MBio. May 28; 2019IL-27 and TCR Stimulation Promote T Cell Expression of Multiple Inhibitory Receptors
ImmunoHorizons. Jan 01; 20192018
Alarmin S100A11 initiates a chemokine response to the human pathogen Toxoplasma gondii
Nature Immunology. Nov 19; 2018Glycolysis is important for optimal asexual growth and formation of mature tissue cysts by Toxoplasma gondii
International journal for parasitology. Aug 31; 2018Sex-specific gene expression differences are evident in human embryonic stem cells and during in vitro differentiation of human placental progenitor cells
Stem Cells and Development. July 11; 2018The maternal vaginal microbiome partially mediates the effects of prenatal stress on offspring gut and hypothalamus.
Nature Neuroscience. July 9; 2018Culture-independent profiling of the stool microbiome to identify microbial species associated with a diarrheal outbreak in an immunocompromised mouse colony.
Comparative Medicine. June 13; 2018Commensal microbes induce serum IgA responses that protect against polymicrobial sepsis.
Cell Host Microbe. Feb 22; 2018CD8+ T cells lack local signals to produce IFN-γ in the skin during leishmania infection.
Journal of Immunology. Jan 24; 2018MicrobiomeDB: a systems biology platform for integrating, mining and analyzing microbiome experiments
Nucleic Acids Research. Jan 4; 20182017
Involvement of Innate Immune System in Late Stages of Inherited Photoreceptor Degeneration.
Scientific Reports. Dec 20; 2017Replication Defective Viral Genomes Exploit A Cellular Pro-Survival Mechanism To Establish Viral Persistence.
Nature Communications. Oct 6; 2017An oxidative central metabolism enables Salmonella to utilize microbiota-derived succinate.
Cell Host and Microbe. Sept 13; 2017Cutaneous leishmaniasis induces a transmissible dysbiotic skin microbiome that promotes increased skin inflammation.
Cell Host and Microbe. July 12; 2017Stress during pregnancy alters temporal and spatial dynamics of the maternal and offspring microbiome in a sex-specific manner
Scientific Reports. Mar 7; 2017T Regulatory Cells Support Plasma Cell Populations in the Bone Marrow.
Cell Reports. Feb 21; 2017CD8 T cell cytotoxicity mediates pathology in the skin by inflammasome activation and IL-1β production.
PLOS Pathogens. Feb 13; 2017Inactivation of interferon receptor promotes the establishment of immune privileged tumor microenvironment.
Cancer Cell. Feb 13; 20172016
STAT1 signaling in astrocytes is essential for control of Toxoplasma gondii in the central nervous system.
MBio. Nov 8; 2016Activity of uncleaved caspase-8 controls anti-bacterial immune defense and TLR-induced cytokine production independent of cell death.
PLOS Pathogens. Oct 13; 2016Divergent isoprenoid biosynthesis pathways in Staphylococcus species constitute a drug target for treating infections in companion animals.
mSphere. Sept 28; 2016Meta-transcriptome profiling of the human-Leishmania braziliensis cutaneous lesion.
PLOS Neglected Tropical Diseases. Sept 15; 2016Cutting Edge: IL-4, IL-21, and IFN-g Interact to Govern TBET and CD11c Expression in TLR-Activated B Cells.
Cutting Edge: Journal of Immunology. July 18; 2016Suppression of type I interferon signaling overcomes the oncogene-induced senescence and mediates melanoma development and progression.
Cell Reports. April 5; 2016T Cell Receptor-Induced NF-kB signaling and transcriptional activation are regulated by STIM1- and Orai1-mediated calcium entry.
J Biol Chem. Jan 29; 2016Type I Interferons Control Proliferation and Function of Intestinal Epithelium.
Mol Cell Biol. Jan 25; 20162015
IL-4 dependent, eosinophil-mediated support of nematode growth occurs in the context of an innate response to tissue injury.
PLOS Pathogens. Dec 31;11(12)image selected as PLOS Pathogens feature image for Jan 2016
Genome sequencing reveals clonal dynamics of methicillin-resistant Staphylococcus aureus in the same household in the context of clinical disease in a person and a dog
Veterinary Microbiology. Nov 18;180(3-4):304-7Complete genome sequence and methylome of Staphylococcus schleiferi, an important cause of skin and ear infections in veterinary medicine.
Genome Announcements. Sep 10;3(5)Skin Resident Memory CD4+ T Cells Enhance Protection Against leishmania major Infection.
Journal of Experimental Medicine. vol. 212 no. 9also see symposis titled Skin-resident T cells keep parasites on a leish
The Orphan Nuclear Receptor TLX is an Enhancer of STAT1-mediated Transcription and Immunity to Toxoplasma gondii.
PLOS Biology. Jul 21;13(7)also see symposis titled Tuning up STAT1
2014
Matrix metalloproteinase 9 production by monocytes is enhanced by TNF-α and participates in the pathology of human cutaneous leishmaniasis.
PLOS Neglected Tropical Diseases. Nov 13;8(11)Intermediate monocytes contribute to pathologic immune response during leishmania braziliensis infection.
Journal of Infectious Diseases. Jan 15;211(2):274-82Protozoan Parasites and Type I Interferon: A Cold Case Reopened.
Trends in Parasitology. Oct;30(10):491-8Genomic Profiling of human leishmania braziliensis lesions identifies transcriptional modules associated with cutaneous immunopathology.
Journal of Investigative Dermatology. Jan;135(1):94-101Bystander chronic infection negatively impacts development of CD8+ T cell memory.
Immunity. May 15;40(5):801-13Differential Induction of TLR3-dependent Innate Immune Signaling by Closely Related Parasite Species.
PLOS One. Feb 5;9(2)Human Classical Monocytes Control the Intracellular Stage of leishmania braziliensis by Reactive Oxygen Species.
Journal of Infectious Diseases. Apr 15;209(8):1288-962013
Cytotoxic T cells Mediate Pathology and Metastasis in Cutaneous leishmaniasis.
PLOS Pathogens. July;9(7)2012 and earlier
The cytokines interleukin 27 and interferon-γ promote distinct Treg cell populations required to limit infection-induced pathology.
Immunity. Sep 21;37(3):511-23Natural resistance-associated macrophage protein is a cellular receptor for sindbis virus in both insect and mammalian hosts.
Cell Host and Microbe. Aug 18;10(2):97-104A systems biological view of intracellular pathogens.
Immunological Reviews. Mar;240(1):117-28Integrative genomic approaches highlight a family of parasite-specific kinases that regulate host responses.
Cell Host and Microbe. Aug 19;8(2):208-18Combinatorial effects of interleukin 10 and interleukin 4 determine the progression of hepatic inflammation following murine enteric parasitic infection.
Hepatology. Jun;51(6):2162-71Apicomplexan parasites co-opt host calpains to facilitate their escape from infected cells.
Science. May 8;324(5928):794-7Eosinophil deficiency compromises parasite survival in chronic nematode infection.
The Journal of Immunology. Feb 1;182(3):1577-83Immunity to Trichinella spiralis muscle infection.
Veterinary Parasitology. Feb 23;159(3-4):245-8*Co-first authors
